Table 1. Comparison of organelle marker trafficking characteristics in different model systems from literature.
Model | Marker | Source | Speed in µm/s | Fraction | Rel. flux in | Abs. flux in | |
---|---|---|---|---|---|---|---|
Antero | Retro | Pausing | Antero dir. | Org./µm/min | |||
Mouse thalamocortical neurons | Neuropeptide Y (NPY) | Nassal et al. | 1.518 | 1.073 | 0.13/0.22 | 0.61/0.82 | 0.052/0.025 |
Mouse thalamocortical neurons | NPY | Knabbe et al. | 2.14 | 1.4 | 0.11 | ||
Mouse sciatic nerve motor neurons | HcT/Neurotrophin | Sleigh et al. | 2.5–2.8* | 0.01* | |||
Mouse sciatic nerve sensory neurons | HcT/Neurotrophin | Sleigh et al. | 1.8* | 0.005* | |||
Mouse thalamocortical neurons | LAMP1 | Nassal et al. | 2.371 | 1.476 | 0.1298 | 0.54 | 0.035 |
Mouse thalamocortical neurons | RAB7 | Nassal et al. | 2.344 | 1.37 | 0.085 | 0.51 | 0.017 |
Mouse cultured cortical neurons | Sema3A | de Wit et al. | 0.78 | 0.43 | 0.22 | ||
Mouse cultured hippocampal neurons | NPY | Bittins et al. | 1.14 | 0.75 | 0.023* | ||
Rat cultured hippocampal neurons | tPA | Kwinter et al. | 1.23 | 1.28 | 0.16 | ||
Rat cultured hippocampal neurons | BDNF | Cavolo et al. | 1.37 | 1.42 | |||
Rat cultured hippocampal neurons | LAMP1 | Boecker et al. | 2 | 1.5* | 0.5$§ | ||
Human iPSC derived cultured neurons | LAMP1 | Boecker et al. | 1.5 | 1* | 0.5$§ | ||
Mouse cultured hippocampal neurons | LAMP1 | De Pace et al. | 1.7 | ||||
Mouse cultured hippocampal neurons | LAMP1 | Snouwaert et al. | 0.85* | 0.75* | |||
Rat cultured hippocampal neurons | RAB7 | Boecker et al. | 1* | 1* | 0.29$§ | ||
Human iPSC (induced pluripotent stem cell) derived cultured neurons | RAB7 | Boecker et al. | 0.7* | 0.9* | 0.25$§ | ||
Rat cultured cortical neurons | RAB7 | Castle et al. | 0.57 | 0.57 | 0.73/0.62§ | ||
Rat cultured DRG neurons | RAB7 | Zhang et al. | 0.31 | 0.53 | 0.33$ | ||
Drosophila larval motor neurons | Ilp-2 | Lund et al. | 0.9* | 0.75* | 0.1* | 0.4* | |
Drosophila larval motor neurons | ANF | Sung et al. | 0.78* | 0.78* | |||
Drosophila larval motor neurons | RAB7 | Lund et al. | 0.9* | 0.85* | 0.15* | 0.25* | |
Drosophila larval motor neurons | Spinster | Lund et al. | 0.95* | 0.85* | 0.1* | 0.4* | |
C. elegans larval motor neurons | ANF | Barkus et al. | 1.14 | 0.41 | 0.13 |
Values have been estimated from graph in figures, §comparability issues, $values were transformed from original for better comparability.