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. 2022 Oct 18;122(12):1988–2000. doi: 10.1055/a-1896-6992

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The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. ( https://creativecommons.org/licenses/by-nc-nd/4.0/ )

This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License, which permits unrestricted reproduction and distribution, for non-commercial purposes only; and use and reproduction, but not distribution, of adapted material for non-commercial purposes only, provided the original work is properly cited.

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Fig. 2 — Platelet-CLEC-2 promotes thrombus growth at arterial shear in mice ex vivo . ( A ) Washed platelets from a CLEC-2 ^−/− (clec1b ^fl/fl GPIbα-Cre ⁺ ) mouse was donated to the whole blood of a secondary CLEC-2 ^−/− mouse to match WT (clec1b ^fl/fl GPIbα-Cre ⁻ ) platelet counts. The red-dotted line represents median platelet count of littermate WT controls. ( B i) Thrombus surface coverage was measured over 4 minutes using DiOC6 fluorescence (2 µM). ( Bii ) Subsequent area under the curve (AUC) was calculated (a.u. = arbitrary units) and ( Biii ) thrombus formation after 2 and 4 minutes is shown. ( Biv ) Representative images shown after 4 minutes ( n = 5 mice). The statistical significance between two groups was analyzed using an unpaired t-test. * p < 0.05, *** p < 0.001.