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. 2022 Dec 3;30(12):1662–1670.e4. doi: 10.1016/j.chom.2022.11.003

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Elsevier has created a Monkeypox Information Center (https://www.elsevier.com/connect/monkeypox-information-center) in response to the declared public health emergency of international concern, with free information in English on the monkeypox virus. The Monkeypox Information Center is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its monkeypox related research that is available on the Monkeypox Information Center - including this research content - immediately available in publicly funded repositories, with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the Monkeypox Information Center remains active.

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Orthopox protein immunodominance; refers to Table S1

The IEDB was mined for experimentally defined epitopes derived from Orthopoxviruses. A total of 47 different antigens were identified as the protein source for defined epitopes, corresponding to 19 and 39 antigens associated with CD4 ⁺ or CD8⁺ epitopes, respectively. The pie charts represent the total proteins recognized by CD4⁺ and CD8⁺ as defined by the IEDB and listed in Table S1. The most immunodominant antigens are listed in the figure legend, and the remaining antigens (“others”) are colored in gray.