Table 2.
MNI coordinates | |||||||
---|---|---|---|---|---|---|---|
H | x | y | z | t | k cluster | p FWE cluster level | |
HC vs. diagnostic group | |||||||
HC > MDD | |||||||
35% hippocampus | L | −30 | −31.5 | −12 | 4.63 | 1554 | 0.033 |
15% parahippocampal gyrus | |||||||
14% fusiform gyrus | |||||||
HC > SSD | |||||||
29% superior temporal gyrus | R | 63 | −1.5 | 4.5 | 5.31 | 8239 | 8.29*10−9 a |
19% central operculum | |||||||
17% middle temporal gyrus | |||||||
30% central operculum | L | −46.5 | 4.5 | −1.5 | 5.23 | 2315 | 0.0009b |
27% frontal operculum | |||||||
25% anterior insula | |||||||
41% fusiform gyrus | L | −37.5 | −31.5 | −13.5 | 4.95 | 3420 | 6.27*10−5 c |
15% hippocampus | |||||||
11% parahippocampal gyrus | |||||||
76% thalamus proper | B | −3 | −12 | 15 | 4.85 | 1708 | 0.004d |
Differences between diagnostic groups | |||||||
MDD < BD | |||||||
34% medial orbital gyrus | R | 9 | 21 | −10.5 | 4.45 | 961 | 0.041 |
28% subcallosal area | |||||||
21% anterior cingulate gyrus | |||||||
MDD > SSD | |||||||
78% fusiform gyrus | L | −37.5 | −33 | −24 | 5.81 | 1196 | 0.02e |
11% occipital fusiform gyrus | |||||||
10% inferior temporal gyrus | |||||||
69% fusiform gyrus | R | 36 | −13.5 | −34.5 | 4.59 | 1695 | 0.006 |
31% inferior temporal gyrus | |||||||
BD > SSD | |||||||
68% fusiform gyrus | R | 37.5 | −37.5 | −21 | 4.88 | 1769 | 0.004f |
24% exterior cerebellum | |||||||
26% medial frontal cerebrum (R) | B | 6 | 24 | −12 | 4.67 | 1671 | 0.005g |
19% anterior cingulate gyrus (B) | |||||||
18% superior medial frontal gyrus (R) |
Only areas ≥10% are included. Letters indicate clusters which were also significant at FWE peak level.
H hemisphere, R right, L left, B bilateral.
aalso significant at p < 0.05 FWE peak-level corrected, k = 571, p = 0.002.
balso significant at p < 0.05 FWE peak-level corrected, k = 164, p = 0.003.
calso significant at p < 0.05 FWE peak-level corrected, k = 81, p = 0.009.
dalso significant at p < 0.05 FWE peak-level corrected, k = 41, p = 0.015.
ealso significant at p < 0.05 FWE peak-level corrected, k = 113, p = 0.0001.
falso significant at p < 0.05 FWE peak-level corrected, k = 48, p = 0.003.
galso significant at p < 0.05 FWE peak-level corrected, k = 19, p = 0.031.