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. 2022 Jul 15;27(10):4234–4243. doi: 10.1038/s41380-022-01687-4

Table 2.

Results of FWE-cluster level significant post-hoc t-tests.

MNI coordinates
H x y z t k cluster p FWE cluster level
HC vs. diagnostic group
HC > MDD
 35% hippocampus L −30 −31.5 −12 4.63 1554 0.033
 15% parahippocampal gyrus
 14% fusiform gyrus
HC > SSD
 29% superior temporal gyrus R 63 −1.5 4.5 5.31 8239 8.29*10−9 a
 19% central operculum
 17% middle temporal gyrus
 30% central operculum L −46.5 4.5 −1.5 5.23 2315 0.0009b
 27% frontal operculum
 25% anterior insula
 41% fusiform gyrus L −37.5 −31.5 −13.5 4.95 3420 6.27*10−5 c
 15% hippocampus
 11% parahippocampal gyrus
 76% thalamus proper B −3 −12 15 4.85 1708 0.004d
Differences between diagnostic groups
MDD < BD
 34% medial orbital gyrus R 9 21 −10.5 4.45 961 0.041
 28% subcallosal area
 21% anterior cingulate gyrus
MDD > SSD
 78% fusiform gyrus L −37.5 −33 −24 5.81 1196 0.02e
 11% occipital fusiform gyrus
 10% inferior temporal gyrus
 69% fusiform gyrus R 36 −13.5 −34.5 4.59 1695 0.006
 31% inferior temporal gyrus
BD > SSD
 68% fusiform gyrus R 37.5 −37.5 −21 4.88 1769 0.004f
 24% exterior cerebellum
 26% medial frontal cerebrum (R) B 6 24 −12 4.67 1671 0.005g
 19% anterior cingulate gyrus (B)
 18% superior medial frontal gyrus (R)

Only areas ≥10% are included. Letters indicate clusters which were also significant at FWE peak level.

H hemisphere, R right, L left, B bilateral.

aalso significant at p < 0.05 FWE peak-level corrected, k = 571, p = 0.002.

balso significant at p < 0.05 FWE peak-level corrected, k = 164, p = 0.003.

calso significant at p < 0.05 FWE peak-level corrected, k = 81, p = 0.009.

dalso significant at p < 0.05 FWE peak-level corrected, k = 41, p = 0.015.

ealso significant at p < 0.05 FWE peak-level corrected, k = 113, p = 0.0001.

falso significant at p < 0.05 FWE peak-level corrected, k = 48, p = 0.003.

galso significant at p < 0.05 FWE peak-level corrected, k = 19, p = 0.031.