Table 2.
Relationships between VS-vmPFC resting-state (rs)FC and behaviors related to reduced motivation and anhedonia after placebo and L-DOPA.
| Dependent: EEfRT - proportion of hard task choices at 88% probability of winning | |
|---|---|
| Independent: Variables | r, p value |
| VS-vmPFC rsFC | 0.24, 0.039 |
| VS-vmPFC rsFC | 0.24, 0.041 |
| Treatment (L-DOPA or Placebo) | −0.02, 0.885 |
| CRP (> or ≤2 mg/L) | −0.07, 0.557 |
| VS-vmPFC rsFC | 0.16, 0.177 |
| Treatment (L-DOPA or Placebo) | −0.04, 0.722 |
| CRP (> or ≤2 mg/L) | −0.10, 0.421 |
| FC × Treatment × CRP Interaction | 0.07, 0.567 |
| Dependent: EEfRT - proportion of hard task choices at 50% probability of winning | |
| Independent: Variables | r, p value |
| VS-vmPFC rsFC | 0.29, 0.048 |
| VS-vmPFC rsFC | 0.25, 0.029 |
| Treatment (L-DOPA or Placebo) | 0.05, 0.687 |
| CRP (> or ≤2 mg/L) | −0.23, 0.046 |
| VS-vmPFC rsFC | 0.20, 0.084 |
| Treatment (L-DOPA or Placebo) | 0.04, 0.744 |
| CRP (> or ≤2 mg/L) | −0.15, 0.210 |
| FC × Treatment × CRP Interaction | 0.01, 0.915 |
| Dependent: EEfRT - proportion of hard task choices at 12% probability of winning | |
| Independent: Variables | r, p value |
| VS-vmPFC rsFC | 0.14, 0.232 |
| VS-vmPFC rsFC | 0.16, 0.188 |
| Treatment (L-DOPA or Placebo) | 0.04, 0.770 |
| CRP (> or ≤2 mg/L) | −0.16, 0.188 |
| VS-vmPFC rsFC | 0.19, 0.115 |
| Treatment (L-DOPA or Placebo) | 0.07, 0.541 |
| CRP (> or ≤2 mg/L) | −0.01, 0.954 |
| FC × Treatment × CRP Interaction | −0.10, 0.379 |
| Dependent: Anhedonia response (change in SHAPS score, post minus pre) | |
| Independent: Variables/Covariates | r, p value |
| VS-vmPFC rsFC | −0.05, 0.671 |
| VS-vmPFC rsFC | −0.06, 0.581 |
| Treatment (L-DOPA or Placebo) | −0.10, 0.404 |
| CRP (> or ≤2 mg/L) | 0.03, 0.803 |
| VS-vmPFC rsFC | 0.24, 0.034 |
| Treatment (L-DOPA or Placebo) | 0.12, 0.313 |
| CRP (> or ≤2 mg/L) | 0.25, 0.031 |
| FC × Treatment × CRP interaction | −0.29, 0.011 |
Correlation coefficient (r) and p values reported for the association between L-DOPA resting-state FC and behavioral measures.
VS-vmPFC FC functional connectivity Z-scores between ventral striatum (VS) and ventromedial prefrontal cortex (vmPFC), L-DOPA levodopa, CRP C-reactive protein, BMI body-mass index, EEfRT effort expenditure task, SHAPS Snaith-Hamilton Pleasure Scale.
Bold text indicates p < 0.05.