Table 1.
Demographic and clinical sample characteristics at baseline shown by sex.
| Characteristic | Men (n = 566) | Women (n = 494) | Total (N = 1060) | P value | |
|---|---|---|---|---|---|
| Age at baseline, years (SD) | 74.8 (7.4) | 72.8 (7.6) | 73.8 (7.6) | <0.001 | |
| APOE ε4 carriers, No. (%) | 249 (44.0) | 213 (43.1) | 462 (43.6) | 0.778 | |
| Diagnosis | Cognitively normal, No. (%) | 168 (29.6) | 191 (38.6) | 359 (33.9) | 0.008 |
| Mild cognitive impairment, No. (%) | 290 (51.2) | 226 (45.7) | 516 (48.7) | ||
| Dementia, No. (%) | 108 (19.0) | 77 (15.6) | 185 (17.5) | ||
| Aβ positive, No. (%) | 292 (51.2) | 268 (54.3) | 560 (52.8) | 0.385 | |
| Education, years (SD) | 16.7 (2.6) | 15.7 (2.7) | 16.2 (2.7) | <0.001 | |
| Race | White, No. (%) | 532 (94.0) | 450 (91.1) | 982 (92.6) | 0.027 |
| Black or African American, No. (%) | 14 (2.5) | 27 (5.5) | 41 (3.9) | ||
| Asian, No. (%) | 12 (2.1) | 6 (1.2) | 18 (1.7) | ||
| Native Hawaiian or Other Pacific Islander, No. (%) | 0 | 2 (0.4) | 2 (0.2) | ||
| American Indian or Alaskan Native, No. (%) | 1 (0.2) | 0 | 1 (0.1) | ||
| More than one race or Unknown, No. (%) | 7 (1.2) | 9 (1.8) | 16 | ||
| Body Mass Index, kg/m2 (SD) | 27.3 (4.2) | 27.2 (6.1) | 27.3 (5.2) | 0.8 | |
| Plasma p-tau181, pg/mL (SD) | 19.0 (10.8) | 17.1 (10.1) | 18.1 (10.5) | 0.003 | |
| Global Aβ PET, SUVR (SD) | 1.20 (0.2) | 1.22 (0.2) | 1.21 | 0.21 | |
| CSF p-tau181, pg/mL (SD) | 25.7 (12.3) | 28.1 (16.0) | 26.8 (14.2) | 0.014 | |
| Composite Fluorodeoxyglucose-PET, SUVR (SD) | 1.25 (0.2) | 1.28 (0.2) | 1.26 (0.2) | 0.001 | |
| Entorhinal cortex tau PET, SUVR (SD) | 1.9 (0.7) | 2.1 (0.9) | 2.0 (0.8) | 0.05 | |