Table 4.
IC50 values (µM) exhibited by the crude polyphenolic extract (CPE) and its fractions (H: hexane, C: chloroform, EA: ethyl acetate, Me: methanol; Aq: aqueous) of C. racemose and the standard drug (M: mitoxantrone) on different cancer (breast, colorectal, hepatoma and leukemia and normal (epithelial and monocular blood) cell lines.
| Sample | Breast cancer cell lines | Colorectal | Hepatoma | Leukemia | Control cell lines | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| KAIMR C1 | MDA-MB-231 | MCF-7 | HCT-8 | Hep G2 | KG-1a | K-562 | HL-60 | Human epithelial | PBMC | ||
| IC 50 values (µM) | CPE | 168.5 | 304.1 | – | 160.0 | 1570 | 644.7 | 2768 | 914.7 | 756.6 | 2940 |
| H | |||||||||||
| C | 92.91 | 3046 | 546.8 | 2344 | 3848 | 1388 | 3001 | 655.6 | 7412 | 1102 | |
| EA | 1722 | ||||||||||
| Me | 1194 | ||||||||||
| Aq | 515 | 118.0 | 48.31 | ||||||||
| M | 0.638 | 0.520 | 1.224 | 0.164 | 0.140 | 0.145 | 0.585 | – | 0.12 | 0.142 | |
Significant values are in bold.