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. 2022 Dec 2;13:7433. doi: 10.1038/s41467-022-35243-z

Fig. 3. Effect of estradiol on pulse generator activity in long-term OVX mice.

Fig. 3

a–c Representative example of GCaMP6 photometry recordings from an OVX mice prior to and 3 and 7 days following treatment with estradiol. d Graph showing the mean ± SEM and individual data points for SI interval following estradiol replacement (one-way ANOVA; P = 0.040; N = 5). e Mean (±SEM) reduction in SE duration following estradiol replacement (one-way ANOVA; P < 0.0001; N = 5). f Mean (±SEM) decrease in relative SE amplitude following estradiol replacement (one-way ANOVA; P = 0.0023; N = 5). Significant differences are indicated by bars with different letter, Dunnett’s multiple comparisons (P < 0.01 or 0.001 in all cases). Source data are provided as a Source Data file.