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. 2022 Dec 2;13:7448. doi: 10.1038/s41467-022-34991-2

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Fig. 5 — A Select GO terms enriched in NCCE+ genes compared to controls. NCCE+ genes are defined as genes nearest to conserved NCCE, where the NCCE are defined as having a 6–16 bp spacing between the centers of a COUP-TFII and an NKX HD motif. Control 1: genes associated with conserved COUP-TFII and NKX HD motifs separated by larger spacings (30–60 bp). Controls 2–4: genes associated with conserved NKX motifs 6–16 bp from conserved scrambled motifs GTAC(G/C), AGTC(G/C), or TGGA(C/T), respectively. B NCCE+ genes in select pathways associated with heart development, neuronal functions, and organ morphogenesis.