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. 2022 Dec 2;5:1323. doi: 10.1038/s42003-022-04268-x

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Average pairwise Pearson correlation values for excitatory neurons in APP/PS1 and WT mice (t₍₁₆₎= 2.008, n = 9WT-EX mice, n = 9 APP-EX mice, p < 0.062, two-tailed). b Relationship between pooled pairwise Pearson correlation values and pairwise interneuronal distance (Two-Way ANOVA, main distance effect F_{(5, 87)} = 4.5, p = <0.001, main genotype effect F_{(1, 87)} = 4.38, p = 0.039, main genotype and distance interaction F_{(5, 87)} = 0.62, p = 0.682). The x axis values represent the maximum limit of the pooled pairwise distances. c Relationship between correlation values and event rates after pooling data according to geometric means of neuronal event rates (two-way ANOVA, main event rate effect F_(6,107) = 9.7, p < 0.0001, main genotype effect F_{(1, 107)} = 24, p = 0.1223, main genotype and event rate interaction F_{(6, 107)} = 0.7, p = 0.58). d, e Average pairwise Pearson correlation values for SOM interneurons (d) (t₍₁₄₎= 1.54, n = 8 WT-SOM mice, n = 8 APP-SOM mice, p = 0.147, two-tailed) and PV interneurons (e) (t₍₁₀₎= 0.16, n = 6 WT-PV mice, n = 6 APP-PV mice, p = 0.95, two-tailed) in APP/PS1 and WT mice. All error bars reflect the mean ± s.e.m.