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. 2022 Oct 26;47(12):3805–3816. doi: 10.1007/s11064-022-03763-1

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — The role of LA in SNI induced mechanical hyperalgesia. (A) The changes of paw withdrawal threshold in calibrated forceps testing demonstrated that LA improved the pain threshold after SNI. n = 6 rats for each group. (B) Western blot analyses showing the LA reversed the changes in the expression of TSLP and TSLPR after SNI in lumbar 4th /5th DRGs of rats. β-actin was used as a loading control. (C) showing the relative band density quantified with its own β-actin of indicated band in (B). (D) Immunofluorescence images were obtained for ATF-3 (green) and TSLPR (red) in the DRGs. Merged double-positive cells were yellow and indicated white-arrow. (E) LA decreased the amounts of merged cells. The tissues were collected on the 7th day after SNI. The scale bar represents 50 μm. n = 4 rats for each group. *P < 0.05 SNI group compared with the control group; and ^#P < 0.05 LA + SNI group compared with SNI group at indicated day. All data are presented as mean ± SEM.