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. 2022 Dec 2;3:38. doi: 10.1186/s43556-022-00104-0

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Length distribution of eccDNAs in CRC and normal tissue samples. a Schematic representation of eccDNA fragmentation mapping. b Schematic representation of circularization of tiled eccDNA. c Histogram of the quantity of eccDNA in each tumor group and normal group. Y-axis does not omit the intervals, only the percentages of 0–500 is increased to visualize the data in normal group. d Volcano plot for the comparison between the eccDNAs in tumor group and normal group. The cutoff values fold change > 2 and P value < 0.05 were utilized to identify differentially expressed genes. e-f Line chart of the percentage of length distribution of eccDNA in each tumor group and N. g Violin plots of the length distribution of eccDNA in 13 T and 13 N (n = 6058 in 13 T, n = 294 in 13 N, P < 0.0001). h Violin plots of the length distribution of eccDNA in each normal group. The dashed line is the median of each group