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. 2022 Dec 2;3:38. doi: 10.1186/s43556-022-00104-0

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Counts distribution, gene expression and chromosomal distribution of eccDNAs in the samples. a Histogram of the eccDNA frequency per 10 Mb in each chromosome. b Pie chart of the percentages of genes (n = 3594) shedding different amounts of eccDNAs. c Heatmap consisting of the logarithm of the normalized values of the highly and lowly expressed genes in each tumor group and N (n = 47 in high and low expression respectively). d Scatter plot of enriched KEGG pathways statistics for genes (n = 3594) contained in eccDNAs in tumor group. e Circos plot of chromosomal distribution and expression levels of high-expressed eccDNAs in tumor group. Concentric circles are, in order from outside to inside: human chromosomes (chr1-chrX), after which the x-axis of all circles is chromosomal coordinate; chromosomal localization of eccDNAs; the basemean of the genes, with the y-axis showing the expression level; Rainfall plot of the degree of gathering of eccDNAs, and the y-axis corresponds to the minimal distance of the region to its two neighboring regions; the foldchange of the genes; the P value of the genes