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. 2022 Dec 2;3:38. doi: 10.1186/s43556-022-00104-0

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Gene regions and functional analysis of eccDNAs with concentrated high expression in CRC. a-b Venn diagram for eccDNA sequences common to each sample in tumor group and N, respectively. c Distribution of eccDNAs intersected in tumor group and N in the indicated genomic regions. d Scatter plot of enriched KEGG pathways statistics for genes (n = 1189) contained in eccDNAs shared in each tumor group. e GO functional classification of genes (n = 1189) contained in eccDNAs shared in each tumor group