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. 2022 Dec 2;3:38. doi: 10.1186/s43556-022-00104-0

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — The association of genes contained in eccDNAs with RNA levels. a Venn diagram for genes differentially expressed in eccDNA and RNA. b GO functional classification of genes highly expressed in both in eccDNA and RNA. c-e Sankey plot for genes in biological process, cellular component and molecular function in Fig. 3b. f Scatter plot of enriched KEGG pathways statistics for genes (n = 219) highly expressed in both in eccDNA and RNA. g Genomic distribution of eccDNA (n = 500) and RNA (n = 461) in tumor group compared with TCGA samples (n = 495). h Genomic distribution of eccDNA in tumor group (n = 6275) and CircleBase (n = 1461)