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. 2022 Dec 2;10(23):e15531. doi: 10.14814/phy2.15531

TABLE 1.

Patient inclusion and exclusion criteria.

Inclusion criteria

  1. Aged between 40 and 80 years.

  • 2

    Diagnosed peripheral artery disease (ankle‐brachial index <0.90) with intermittent claudication.

  • 3

    No major changes in medications for at least 3 months

Exclusion criteria

  1. Foot ulcers, advanced neuropathy, gangrene, or other musculoskeletal condition that could limit exercise performance.

  • 2

    Type 1 diabetes or glycated hemoglobin >8.5%.

  • 3

    A major cardiovascular event within the previous 6 weeks or a planned hospitalization within the next 2 months.

  • 4

    Any cardiovascular condition that impacts safety of completing a cardiopulmonary exercise test, including history of significant left main or three‐vessel coronary artery disease (>70% stenosis), recent myocardial infarction (6 weeks), chest pain during cardiopulmonary exercise test, or >2 mm ST depression during exercise; foot ulcers/advanced neuropathy or other musculoskeletal condition that could limit exercise performance.

  • 5

    Allergy to beets or proton pump inhibitors.

  • 6

    Refusal or inability to abstain from the use of proton pump inhibitors for 24 h prior to testing.