Table 1.
Selection signatures responsible for indigenous sheep adaptation.
| Breeds | Country | Gene | Function | Reference |
|---|---|---|---|---|
| Prairie Tibetan, Valley Tibetan, Oula, Ayinbuluke, Cele Black, Hu, Tan, Small Tail Han, Wuzhumuqin and Australian Merino sheep | China | RXFP2 | Horn phenotype | Pan et al., 2018 |
| MITF, MSRB3, SLC26A4 | Hearing | |||
| SMDC1, SOX6 | Muscle development | |||
| PRD-SPRRII | Rumen development | |||
| Kefis, Adane, Arabo, Gafera-Washera, Molalu-Menz, Bonga, Gesses, Kido, Doyogena, ShubiGemo and Loya | Ethiopia | ALX4, HOXB13, BMP4 | Limp development and Tail formation | Ahbara et al., 2019 |
| NPR2, HINT2, SPAG8, INSR | Growth traits | |||
| TRPM8 | Regulation of body temperature | |||
| DNAJC18 | Response to heat stress | |||
| Barbarine, Noire de Thibar and Queue fine de l'Ouest | Tunisia | CDS2, PROKR1, BMP2 | Lipid storage /Tail fatness | Baazaoui et al., 2021 |
| Changthangi, Deccani,and Garole | India | TRPM8 | Cold adaptation | Saravanan et al., 2021 |
| Garole | RAD1 | Immunity | ||
| Changthangi and Deccani | IL2, JADE2, FGF2, SPP2, RMI1 and TSHR | Growth and body growth | ||
| Bariga Negra, Morada Nova, Rabo Largo, Santa Ines and Somalis. | Brazil | GNG2; PTGDR; PLEKHO2; USP3; APH1B; RAB8B | Immune response | Paim et al., 2022 |
| PTGDR; PLEKHO2; ZNF609, CAPSL; IL7R; | Inflammation response | |||
| CA12 | Dehydration and Kidney function, water balance | |||
| PTGDR | Body Temperature; Thermogenesis | |||
| Adane, Arabo, Bonga, Doyogena, Kefis, Segentu, Gesses, Kido, Menz, Shubi Gemo and Washera | Ethiopia | ITPR2, FAM162A, GATA6, GNGT1 and HIF3A. | Hypoxia | Wiener et al., 2021 |
RXFP2: Relaxin Family Peptide Receptor 2, MITF: Melanocyte inducing transcription factor, MSRB3: Methionine Sulfoxide Reductase B3, SLC26A4: solute carrier family 26 member 4, SMDC1: SAYSVFN motif domain containing 1, SOX6: SRY-Box Transcription Factor 6, PRD-SPRRII: Small proline-rich protein type II, ALX4: Aristaless-Like Homeobox 4, HOXB13: Homeobox Protein Hox-B13, BMP4: Bone Morphogenetic Protein 4, TRPM8: Transient Receptor Potential Cation Channel Subfamily M, member 8, NPR2: natriuretic peptide receptor 2, HINT2: Histidine Triad Nucleotide Binding Protein 2, SPAG8: Sperm Associated Antigen 8, INSR: Insulin Receptor, DNAJC18: DnaJ Heat Shock Protein Family (Hsp40) Member C18, CDS2: CDP-Diacylglycerol Synthase 2, PROKR1: Prokineticin Receptor 1, BMP2: Bone Morphogenetic Protein 2, RAD1 Checkpoint DNA Exonuclease, IL2: interleukin 2, JADE2: E3 Ubiquitin-Protein Ligase Jade-2, FGF2: Fibroblast Growth Factor 2, SPP2: Secreted Phosphoprotein 2, RMI1: RecQ Mediated Genome Instability 1: TSHR: thyroid stimulating hormone receptor, GNG2: G Protein Subunit Gamma 2, PTGDR: Prostaglandin D2 Receptor, PLEKHO2: Pleckstrin Homology Domain Containing O2, USP3: Ubiquitin Specific Peptidase 3; APH1B: Aph-1 Homolog B, Gamma-Secretase Subunit, RAB8B: Ras-Related Protein Rab-8B, PTGDR: Prostaglandin D2 Receptor; PLEKHO2: Pleckstrin Homology Domain Containing O2, ZNF609: Zinc Finger Protein 609, CAPSL: Calcyphosine Like, IL7R: Interleukin 7 Receptor, CA12: Carbonic Anhydrase 12, ITPR2: Inositol 1,4,5-Trisphosphate Receptor Type 2, FAM162A: Family With Sequence Similarity 162 Member A, GATA6: GATA Binding Protein 6, GNGT1: G Protein Subunit Gamma Transducin 1 and HIF3A: Hypoxia Inducible Factor 3 Subunit Alpha.