Table 3.
The diagnostic performance of the Anyplex MTB/NTM for MTBC detection in clinical specimens from pediatric patients (age ≤15).
| Specimens | Culture-positive |
Culture-negative |
Sensitivity (%) (95%CI) | Specificity (%) (95%CI) | PPV (%) (95%CI) | NPV (%) (95%CI) | Percent agreement (%) (95%CI) | ||
|---|---|---|---|---|---|---|---|---|---|
| PCR + | PCR - | PCR + | PCR - | ||||||
| Pulmonary | 10 | 0 | 1 | 82 | 100 (69.2–100) |
98.8 (93.5–100) |
90.9 (58.7–99.8) |
100 (95.6–100) |
98.9 (96.8–100) |
| Extrapulmonary | 18 | 5 | 12 | 218 | 78.3 (56.3–92.5) |
94.8 (91.1–97.3) |
60 (40.6–77.3) |
97.8 (94.8–99.3) |
93.3 (90.2–96.4) |
| Overall | 28 | 5 | 13 | 300 | 84.8 (68.1–94.9) |
95.8 (93–97.8) |
68.3 (51.9–81.9) |
98.4 (96.2–99.5) |
94.8 (92.5–97.1) |