Table 2.
Comparison of Equations for Estimating GFR
| CKDEPI21 | CKDEPI09 | CKDEPI09-NB | MDRD | MDRD-NB | |
|---|---|---|---|---|---|
| Bias: median difference between measured GFR and estimated GFR (95% CI), by subpopulationa | |||||
| Total | 2.8 (1.2-4.4) | 5.9 (4.2-7.6) | 6.4 (4.6-8.1) | 14.2 (12.3-16.0) | 15.1 (13.3-16.9) |
| Asian | 2.3 (-2.2 to 6.9) | 5.6 (0.3-11.0) | 5.6 (0.3-11.0) | 16.4 (12.8-19.9) | 16.4 (12.8-19.9) |
| Hispanic | 1.9 (-2.0 to 5.8) | 5.6 (1.7-9.5) | 5.6 (1.7-9.5) | 13.0 (8.4-17.5) | 13.0 (8.34 17.5) |
| Black | 9.0 (0.9-17.1) | −1.2 (−10.0 to 7.7) | 12.3 (4.5-20.1) | 6.3 (−2.6 to 15.2) | 22.9 (14.0-31.7) |
| White | 2.9 (1.0-4.8) | 6.4 (4.4-8.3) | 6.4 (4.4-8.3) | 15.1 (13.0-17.2) | 15.1 (13.0-17.2) |
| Precision: interquartile range of the difference between measured GFR and estimated, IQR (P25, P75), by subpopulation | |||||
| Total | 20.1 (−7.6, 12.4) | 19.6 (−4.1, 15.6) | 19.9 (−3.9, 16.0) | 21.1 (3.1, 24.2) | 21.6 (3.5, 25.2) |
| Asian | 18.6 (−8.1, 10.5) | 19.8 (−4.7, 15.1) | 19.8 (−4.7, 15.1) | 22.6 (1.7, 24.3) | 22.6 (1.7, 24.3) |
| Hispanic | 19.9 (−8.5, 11.3) | 20.1 (−4.6, 15.5) | 20.1 (−4.6, 15.5) | 22.2 (0.7, 23.0) | 22.2 (0.7, 23.0) |
| Black | 25.7 (−6.1, 19.6) | 29.4 (−172, 12.2) | 25.4 (−1.8, 23.6) | 27.2 (−9.3, 17.8) | 23.3 (9.1, 32.4) |
| White | 19.7 (−7.1, 12.6) | 19.4 (−3.0, 16.5) | 19.4 (−3.0, 16.5) | 19.7 (5.4, 25.0) | 19.7 (5.4, 25.0) |
| Accuracy: P30, the percent of estimated GFR within 30% of measured GFR (95% CI), by subpopulation | |||||
| Total | 96.4% (94.9%-97.8%) | 94.7% (92.9%-96.4%) | 94.2% (92.4%-96.1%) | 88.7% (86.3%-91.1%) | 86.8% (83.9%-89.3%) |
| Asian | 96.5% (90.1%-100.0%) | 93.0% (87.6%-98.4%) | 93.0% (87.6%-98.4%) | 88.4% (79.7%-94.3%) | 88.4% (79.7%-94.3%) |
| Hispanic | 96.2% (93.6%-98.9%) | 95.7% (92.8%-98.6%) | 95.7% (92.8%-98.6%) | 90.9% (85.8%-94.6%) | 90.9% (85.8%-94.6%) |
| Black | 91.9% (83.2%-100.0%) | 89.2% (79.4%-99.0%) | 81.1% (68.1%-94.1%) | 91.9% (78.1%-98.3%) | 59.5% (42.1%-75.3%) |
| White | 97.0% (94.5%-98.5%) | 95.1% (92.8%-97.5%) | 95.1% (92.8%-97.5%) | 87.2% (83.1%-90.6%) | 87.2% (83.1%-90.6%) |
Notes: All units of GFR in mL/min/1.73 m2. Estimates in this table are normalized to a body surface area of 1.73 m2. The term eGFR denotes estimated GFR by the creatinine-based equation with which it is referenced. NB (Non-Black) refers to equations in which the Black race coefficient was omitted; thus, this equation is only applicable to Black participants. Race is based on participant reporting. Total values do not include multiracial individuals.
Abbreviations: CDKEPI, Chronic Kidney Disease Epidemiology Collaboration; CI, confidence interval; eGFR, estimated glomerular filtration rate; GFR, glomerular filtration rate; IQR, interquartile range; MDRD, Modification of Diet in Renal Disease; mGFR, measured glomerular filtration rate; NB, non-Black.
Positive values indicate underestimation of mGFR by eGFR; negative values indicate overestimation of mGFR by eGFR.