Fig. 3.

Association of 5-mC scores to overall survival and molecular risk factors. A Overall survival of ALK-positive NSCLC from the time point of plasma sampling according to the median 5-mC score of all evaluable patient samples (0.1447). B 5-mC scores in samples from patients with EML4-ALK fusion variant V1/2 and V3 detected in tissue biopsies. Each dot represents one plasma sample, and the number of samples and patients (in brackets) are given per group. Box plot center lines indicate the median, and boxes illustrate the interquartile range with Tukey whiskers. ALK, anaplastic lymphoma kinase; EML4, echinoderm microtubule-associated protein-like 4