Table 6.

Diagnostic value of CpG1-7 in distinguishing LC from NC or BPN

	Specificity (%)	Sensitivity (%)	Positive-LR	Negative-LR	PPV (%)	NPV (%)
LC versus NC	86.19	44.16	3.20	0.65	61.36	75.66
LUAD versus NC	80.97	42.12	2.21	0.71	42.86	80.51
LUSC versus NC	82.48	68.29	3.90	0.38	96.47	27.05
LC versus BPN	56.65	71.43	1.65	0.50	75.12	51.97
LUAD versus BPN	62.23	68.73	1.82	0.50	69.44	61.44
LUSC versus BPN	60.09	75.31	1.89	0.41	87.50	39.61

LC lung cancer, BPN benign pulmonary nodule, NC normal control, LUAD lung adenocarcinoma, LUSC lung squamous cell carcinoma, Positive-LR positive likelihood ratio, Negative-LR negative likelihood ratio, PPV positive predictive value, NPV negative predictive value