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Distribution of the AβX–42/X–40 ratio in cerebrospinal fluid. The histogram shows the distribution of the AβX–42/X–40 ratios measured in cerebrospinal fluid (CSF) using the SULFO-TAG-6E10 detection antibody. Two normal distributions were fitted with the R package “mix-tools” (version 1.2.0). The vertical dashed line shows the intersection of the two curves at a CSF AβX–42/X–40 ratio of 0.058 (threshold). Aβ, amyloid-β
