Table 1.
Characteristics of the study cohort
| All (n = 73)a | Aβ− (n = 37)b | Aβ+ (n = 36)b | P-valuec | |
|---|---|---|---|---|
| Age [mean ± SD] | 69.3 ± 7.8 | 67.1 ± 7.8 | 71.6 ± 7.2 | 0.0126 |
| Female | 42 (57.5%) | 20 (54.1%) | 22 (61.1%) | |
| Male | 31 (42.5%) | 17 (45.9%) | 14 (38.9%) | |
| ApoE4 carrier | 35 (47.9%) | 8 (21.6%) | 27 (75%) | |
| CSF AβX–42/X–40 [mean ± SD] | 0.058 ± 0.025 | 0.082 ± 0.0055 | 0.033 ± 0.0056 | < 0.0001 |
| CSF AβX–42 [pg/mL, mean ± SD] | 380.8 ± 217.8 | 530.0 ± 198.4 | 227.4 ± 96.7 | < 0.0001 |
| CSF AβX–40 [pg/mL, mean ± SD] | 6678.2 ± 2598.4 | 6377.3 ± 2132.2 | 6987.4 ± 3003.2 | 0.5067 |
| CSF t-Tau CSF [pg/mL, mean ± SD]d | 417.5 ± 344.6 | 225.6 ± 80.2 | 614.8 ± 398.5 | < 0.0001 |
| CSF pTau181 [pg/mL, mean ± SD]d, e | 60.0 ± 33.7 | 39.5 ± 11.3 | 81.0 ± 36.0 | < 0.0001 |
Aβ amyloid-β
aFive subjects (out of originally 78) were excluded from the statistical analysis resulting in a final sample size of n = 73
bThe clinical sample was dichotomized according to the AβX–42/X–40 ratio in cerebrospinal fluid (CSF) measured with the MSD Aβ panel 1 (6E10) V-PLEX multiplex assay
cTwo-tailed Mann–Whitney test p-values for the comparison between the groups amyloid-negative (Aβ−, CSF AβX–42/X–40 > 0.058, n = 37) and amyloid-positive (Aβ+, CSF AβX–42/X–40 ≤ 0.058, n = 36)
dCSF levels of total Tau (t-Tau) and phospho-Tau-181 (pTau181) were routinely determined in a clinical laboratory
eFor one subject, the measured pTau181 concentration was < 15.6 pg/mL. For the statistical analysis, this value was artificially set to a fixed value of 15.6 pg/mL