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. 2022 Dec 3;24:22. doi: 10.1186/s12575-022-00185-9

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Cross-validation of predictive efficiency of the prognostic signature. A ROC curves of HCC patients at 1, 2, and 3 years in the TCGA-LIHC (left), GSE14520 (middle), and ICGC-LIRI (right) cohorts. B C-index of each risk signature: 0.705 for our platelet signature, 0.69 for Lin signature, 0.691 for Yi signature, 0.653 for Zhang signature, 0.675 for Su signature, and 0.657 for Wang signature. C Crosswise comparison of survival differences among distinct risk signatures based on the restricted mean survival (RMS) time: Platelet signature (HR: 3.583, 95%CI: 2.508–5.118, p < 0.001), Lin’s signature (HR: 1.147, 95%CI: 1.014–1.192, p < 0.001), Yi’s signature (HR: 1.188, 95%CI: 1.132–1.247, p < 0.001), Zhang’s signature (HR: 1.595, 95%CI: 1.346–1.891, p < 0.001), Su’s signature (HR: 1.306, 95%CI: 1.175–1.452, p < 0.001), and Wang’s signature (HR: 1.492, 95%CI: 1.213–1.836, p < 0.001). D ROC curves of HCC patients at 1, 3, and 5 years in several other published prediction models. E OS curves of HCC patients stratified by other published risk signatures