Table 2.
Results of computerized glycemic variability index
| Pre-mix insulin usage (N = 16) | GLP-1 agonist added on basal insulin usage (n = 16) | p | |
|---|---|---|---|
| All day period (0:00–24:00) | |||
| SD | 43.9 [34.4, 60.6] | 36.0 [27.7, 47.5] | 0.017a |
| CV | 0.24 [0.21, 0.29] | 0.20 [0.15, 0.26] | 0.046a |
| MAGE | 114.2 [91.4, 151.4] | 78.7 [66.8, 124.8] | 0.006a |
| AUCt | 50869.2 [44430.2, 66563.7] | 53484.3 [41642.7, 59404.7] | 0.918 |
| AUC180 | 31850.4 [15978.1, 55968.9] | 34434.3 [12336.0, 46503.3] | 0.535 |
| AUCn | 18672.2 [9534.4, 28527.5] | 19419.5 [13836.7, 28965.2] | 0.408 |
| AUC70 | 0.0 [0.0, 175.0] | 0.0 [0.0, 0.0] | 0.674 |
| LBGI | 0.07 [0.00, 0.41] | 0.00 [0.00, 0.18] | 0.463 |
| HBGI | 9.68 [5.41, 20.28] | 9.46 [4.14, 14.48] | 0.535 |
| M-value | 23.47 [13.12, 45.15] | 18.45 [10.49, 27.86] | 0.088 |
| CONGA1 | 28.07 [23.33, 39.29] | 23.25 [19.93, 34.58] | 0.079 |
| CONGA2 | 42.80 [35.88, 56.29] | 36.45 [31.46, 54.49] | 0.049a |
| CONGA4 | 56.94 [45.81, 70.33] | 50.49 [38.80, 62.95] | 0.020a |
| TIR | 39.0 [24.1, 71.7] | 52.6 [31.4, 77.6] | 0.305 |
| Duration above upper limit (%) | 61.0 [27.0, 76.0] | 47.4 [19.9, 68.6] | 0.352 |
| Duration within limits (%) | 39.0 [24.1, 71.7] | 52.6 [31.4, 77.6] | 0.453 |
| Duration below lower limit (%) | 0.0 [0.0, 0.6] | 0.0 [0.0, 0.0] | 0.624 |
| Nocturnal period (00:00–06:00) | |||
| SD | 14.8 [9.3, 20.2] | 11.5 [9.39, 19.9] | 0.605 |
| CV | 0.09 [0.08, 0.13] | 0.07 [0.06, 0.13] | 0.796 |
| MAGE | 34.9 [23.1, 50.4] | 32.9 [25.1, 60.0] | 0.642 |
| AUCt | 11771.3 [8691.5, 14551.0] | 11015.0 [8383.6, 12973.3] | 0.569 |
| AUC180 | 3822.2 [260.1, 12524.9] | 2262.3 [13.6, 6654.3] | 0.363 |
| AUCn | 6176.7 [2794.0, 8419.7] | 7392.8 [5662.3, 8730.4] | 0.278 |
| AUC70 | 0.0 [0.0, 0.0] | 0.0 [0.0, 0.0] | 0.715 |
| LBGI | 0.09 [0.00, 0.59] | 0.00 [0.00, 0.51] | 0.552 |
| HBGI | 6.24 [1.32, 14.17] | 4.31 [0.86, 8.44] | 0.379 |
| M-value | 8.96 [5.01, 22.66] | 7.71 [3.32, 15.82] | 0.408 |
| CONGA1 | 13.20 [9.52, 16.57] | 10.61 [8.53, 13.21] | 0.438 |
| CONGA2 | 14.12 [11.61, 19.84] | 12.58 [10.17, 16.80] | 0.234 |
| CONGA4 | 11.64 [9.15, 13.36] | 9.87 [8.08, 14.26] | 0.642 |
Each glycemic variability index is presented as the median [Q1, Q3]. Continuous variants were analyzed by Wilconxon singed-rank test
SD standard deviation; CV coefficient of variation; MAGE mean amplitude of glycemic excursions; AUC area under curve; LBGI low blood glucose index; HBGI high blood glucose index; M-value weighted average of glucose value; CONGA continuous overlapping net glycemic action; TIR time in range
adenotes p value < 0.05