Fig. 6.

CD44 removal weakens angiogenic function of plasma exosomes by regulating miRNA-FGFR2 signaling. A Venn diagram of miRNAs regulating FGFR signaling pathway putatively overlapping with highly expressed in KOMI mouse plasma exosomes. B Real-time quantitative polymerase chain reaction (RT-qPCR) analysis of the two candidate miRNAs, miR-125b-5p and miR-223-3p, in border zone of CD44 WT and KO infarcted hearts. Data were normalized to U6 (n = 4–7). C TargetScan database predicated interaction between miR-125b-5p, miR-223-3p and FGFR2 3’-untranslated region (3’-UTR). D, E Western blot analysis of target genes of miR-125b-5p and miR-223-3p in the FGFR2 pathway (n = 3). *P < 0.05, **P < 0.01