Table 1.
Clinical characteristics according to short-term changes in FPG status in women
| Variables | All (n = 8272) |
NFG to NFG (n = 5092) |
NFG to IFG (n = 1233) |
NFG to T2DM (n = 107) |
IFG to NFG (n = 445) |
IFG to IFG (n = 1160) |
IFG to T2DM (n = 235) |
|---|---|---|---|---|---|---|---|
| Continuous variables, mean ± SD | |||||||
| Age (years) | 49.9 ± 6.9 | 48.8 ± 7.4 | 51.5 ± 5.3 | 50.5 ± 6.8 | 51.0 ± 6.5 | 52.2 ± 5.2 | 51.0 ± 6.1 |
| SBP (mmHg) | 116 ± 17.6 | 113 ± 16.6 | 118.2 ± 17.5 | 123.5 ± 17.3 | 120.1 ± 18.4 | 122.4 ± 18.2 | 125.7 ± 19.5 |
| DBP (mmHg) | 72.1 ± 10.5 | 70.9 ± 10.3 | 72.8 ± 10.5 | 74.7 ± 11.1 | 74.8 ± 10.4 | 74.4 ± 10.1 | 76.6 ± 11.2 |
| BMI (kg/m2) | 27.9 ± 5.7 | 26.9 ± 5.1 | 28.4 ± 5.9 | 32.5 ± 6.2 | 28.5 ± 5.8 | 29.7 ± 6.3 | 32.6 ± 6.6 |
| TC (mmol/L) | 5.4 ± 1.1 | 5.3 ± 1.0 | 5.5 ± 1.1 | 5.4 ± 1.2 | 5.6 ± 1.1 | 5.7 ± 1.0 | 5.6 ± 1.2 |
| FPG (mmol/L) | 5.2 ± 0.6 | 4.9 ± 0.4 | 5.2 ± 0.3 | 5.7 ± 0.7 | 5.8 ± 0.2 | 6.0 ± 0.3 | 6.3 ± 0.4 |
| Categorical variables, number (%) | |||||||
| Ever smoker | 2976 (36) | 1677 (32.9) | 521 (42.3) | 33 (30.8) | 161 (36.2) | 496 (42.8) | 88 (37.4) |
| Hypertension (yes) | 1995 (24.1) | 905 (17.8) | 341 (27.7) | 43 (40.2) | 139 (31.2) | 444 (38.3) | 123 (52.3) |
| Hypercholesterolemia (yes) | 4546 (55) | 2559 (50.3) | 727 (59) | 60 (56.1) | 273 (61.3) | 785 (67.7) | 142 (60.4) |
| Outcomes, the incidence rate per 1000 person-years (95%CI) | |||||||
| Cancer Mortality* | 3.34 (3.05–3.65) | 2.43 (2.11–2.80) | 4.57 (3.78–5.47) | 6.64 (3.18–12.21) | 4.15 (2.92–5.72) | 4.36 (3.58–5.26) | 4.34 (2.65–6.70) |
| CV Mortality | 1.85 (1.65–2.08) | 1.25 (1.03–1.50) | 2.41 (1.86–3.08) | 2.31 (0.63–5.91) | 2.19 (1.34–3.38) | 2.61 (2.02–3.32) | 5.43 (3.55–7.95) |
| All-cause Mortality | 7.35 (6.93–7.79) | 5.38 (4.91–5.88) | 9.53 (8.39–10.78) | 11.54 (7.05–17.83) | 9.31 (7.44–11.51) | 10.05 (8.85–11.36) | 12.73 (9.74–16.36) |
*Only ARIC and TLGS participants were assessed and followed-up for cancer mortality outcomes
As appropriate, baseline data are shown as mean ± standard deviation (SD) or number (percent). Outcome data are shown as incidence rate per 1000 person-years (95% CI)
NFG normal fasting glucose, IFG impaired fasting glucose based on ADA cut-offs (100 mg/dl), T2DM type 2 diabetes mellitus; SBP: systolic blood pressure, DBP diastolic blood pressure, BMI body mass index, FPG fasting plasma glucose, TC total cholesterol, CV cardiovascular, CI confidence interval