Table 2.
Clinical characteristics according to short-term changes in FPG status in men
| Variables | All (n = 6106) |
NFG to NFG (n = 2996) |
NFG to IFG (n = 1102) |
NFG to T2DM (n = 74) |
IFG to NFG (n = 417) |
IFG to IFG (n = 1318) |
IFG to T2DM (n = 199) |
|---|---|---|---|---|---|---|---|
| Continuous variables, mean ± SD | |||||||
| Age (years) | 50.1 ± 6.9 | 48.6 ± 7.8 | 51.3 ± 5.5 | 49.3 ± 7.1 | 50.4 ± 6.5 | 52.0 ± 5.2 | 52.4 ± 5.6 |
| SBP (mmHg) | 118.6 ± 15.6 | 116.4 ± 15 | 119.4 ± 15.8 | 120.6 ± 13.6 | 120.0 ± 16.3 | 121.3 ± 15.3 | 126 ± 17.1 |
| DBP (mmHg) | 75.5 ± 10.3 | 74.8 ± 10 | 75.8 ± 10.5 | 77.3 ± 8.6 | 75.8 ± 11.4 | 76.3 ± 10.2 | 78.4 ± 11.2 |
| BMI (kg/m2) | 27.3 ± 4 | 26.7 ± 3.8 | 27.5 ± 4 | 30.1 ± 4.7 | 27.5 ± 4.1 | 28 ± 4 | 30 ± 4.3 |
| TC (mmol/L) | 5.2 ± 1 | 5.1 ± 1 | 5.3 ± 1 | 5.1 ± 1.1 | 5.3 ± 1 | 5.4 ± 1 | 5.4 ± 1 |
| FPG (mmol/L) | 5.3 ± 0.6 | 4.9 ± 0.4 | 5.3 ± 0.3 | 5.8 ± 0.7 | 5.8 ± 0.3 | 6.0 ± 0.3 | 6.4 ± 0.4 |
| Categorical variables, number (%) | |||||||
| Ever smoker | 3706 (60.7) | 1643 (54.8) | 711 (64.5) | 51 (68.9) | 264 (63.3) | 897 (68.1) | 140 (70.4) |
| Hypertension (yes) | 1403 (23) | 536 (17.9) | 265 (24) | 21 (28.4) | 97 (23.3) | 414 (31.4) | 70 (35.2) |
| Hypercholesterolemia (yes) | 3104 (50.8) | 1368 (45.7) | 587 (53.3) | 35 (47.3) | 215 (51.6) | 784 (59.5) | 115 (57.8) |
| Outcomes, the incidence rate per 1000 person-years (95%CI) | |||||||
| Cancer Mortality* | 4.33 (3.93–4.75) | 3.05 (2.53–3.65) | 5.26 (4.34–6.32) | 4.68 (1.52–10.93) | 4.80 (3.38–6.62) | 4.99 (4.20–5.89) | 5.96 (3.78–8.95) |
| CV Mortality | 2.92 (2.61–3.25) | 1.97 (1.59–2.42) | 3.41 (2.69–4.26) | 4.92 (1.81–10.71) | 2.86 (1.81–4.29) | 3.56 (2.90–4.32) | 6.02 (3.81–9.03) |
| All-cause Mortality | 10.82 (10.21–11.44) | 7.57 (6.80–8.40) | 12.85 (11.42–14.41) | 18.05 (11.31–27.32) | 11.43 (9.22–14.02) | 12.84 (11.56–14.22) | 19.07 (15.02–23.86) |
*Only ARIC and TLGS participants were assessed and followed-up for cancer mortality outcomes
As appropriate, baseline data are shown as mean ± standard deviation (SD) or number (percent). Outcome data are shown as incidence rate per 1000 person-years (95% CI)
NFG normal fasting glucose, IFG impaired fasting glucose based on ADA cut-offs (100 mg/dl), T2DM type 2 diabetes mellitus, SBP systolic blood pressure, DBP diastolic blood pressure, BMI body mass index, FPG fasting plasma glucose, TC total cholesterol, CV cardiovascular, CI confidence interval