Table 6.

Summary of total, direct, indirect and mediated effect results of AAs to mortality through mediators

Pathway		Percentage mediated				Total effect (TE)				Natural direct effect (NDE)				Natural indirect effect (NIE)
AA	Mediator	Estimate	95%CI		P	Estimate	95%CI		P	Estimate	95%CI		P	Estimate	95%CI		P
Biomarker			Lower	Upper			Lower	Upper			Lower	Upper			Lower	Upper
HAA	HDL	− 0.049	− 8.922	9.164	0.987	0.012	0.005	0.019	0.001	0.012	0.005	0.019	0.001	− 0.000006	− 0.0009	0.0009	0.987
HAA	Trigly	− 1.392	− 14.450	2.048	0.542	0.012	0.005	0.019	0.001	0.012	0.005	0.019	0.001	− 0.00017	− 0.0013	0.0002	0.530
HAA	DBP	− 0.615	− 14.124	2.134	0.666	0.009	0.003	0.015	0.006	0.009	0.003	0.015	0.005	− 0.00005	− 0.0008	0.0002	0.661
HAA	BMI	− 0.724	− 16.968	2.089	0.635	0.009	0.003	0.015	0.006	0.009	0.003	0.015	0.005	− 0.00006	− 0.0008	0.0002	0.629
HAA	NUMDZV	0.769	− 3.483	12.295	0.711	0.010	0.004	0.016	0.003	0.009	0.004	0.016	0.003	0.00007	− 0.0003	0.0009	0.711
HAA	CAD	− 2.093	− 19.996	4.708	0.577	0.009	0.003	0.015	0.004	0.009	0.003	0.016	0.003	− 0.0002	− 0.001	0.0004	0.562
PhenoAA	ANG2	19.781	6.688	48.483	0.016	0.010	0.005	0.016	< .0001	0.008	0.003	0.014	0.002	0.002	0.0008	0.0038	0.004
PhenoAA	HDL	0.028	− 4.515	5.645	0.986	0.013	0.007	0.019	< .0001	0.013	0.007	0.019	< .0001	0.000004	− 0.0005	0.0007	0.986
PhenoAA	BMI	− 0.432	− 7.229	1.098	0.638	0.011	0.006	0.016	< .0001	0.011	0.006	0.016	< .0001	− 0.00005	− 0.0007	0.0001	0.636
PhenoAA	NUMDZV	0.067	− 3.467	5.138	0.961	0.011	0.006	0.016	< .0001	0.011	0.006	0.016	< .0001	0.000008	− 0.0004	0.0005	0.961
PhenoAA	LVEF	6.089	0.924	17.785	0.093	0.011	0.006	0.016	< .0001	0.011	0.006	0.015	< .0002	0.0007	0.000	0.002	0.084
PhenoAA	CAD	− 0.620	− 7.942	3.785	0.785	0.011	0.006	0.016	< .0001	0.011	0.006	0.016	< .0001	− 0.0001	− 0.001	0.0004	0.783
PhenoAA	Diabetes	8.153	1.520	22.822	0.043	0.012	0.007	0.017	< .0001	0.011	0.006	0.016	< .0001	0.0010	0.000	0.002	0.034
GrimAA	ANG2	12.264	3.402	26.933	0.014	0.022	0.015	0.029	< .0001	0.011	0.012	0.026	< .0001	0.0027	0.0008	0.0054	0.009
GrimAA	HDL	− 0.659	− 7.671	4.096	0.762	0.023	0.015	0.031	< .0001	0.023	0.015	0.031	< .0001	− 0.00015	− 0.0016	0.0009	0.762
GrimAA	SBP	0.074	− 1.795	3.218	0.920	0.021	0.014	0.029	< .0001	0.021	0.014	0.029	< .0001	0.000016	− 0.0004	0.0006	0.920
GrimAA	BMI	− 0.115	− 3.388	1.175	0.812	0.021	0.014	0.028	< .0001	0.021	0.014	0.028	< .0001	− 0.00002	− 0.0007	0.0002	0.812
GrimAA	NUMDZV	1.166	− 0.535	7.502	0.379	0.022	0.015	0.029	< .0001	0.022	0.014	0.029	< .0001	0.00026	− 0.0001	0.0014	0.376
GrimAA	LVEF	5.277	0.812	15.613	0.065	0.022	0.015	0.029	< .0001	0.021	0.013	0.028	< .0001	0.0012	0.0002	0.0031	0.057
GrimAA	CAD	2.952	− 0.045	11.140	0.164	0.022	0.015	0.029	< .0001	0.021	0.014	0.029	< .0001	0.001	− 0.00001	0.002	0.157

Bold indicates nominally significant at P < 0.05