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. 2022 Dec 3;20:554. doi: 10.1186/s12967-022-03772-2

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Identification of VSX1 as a prognostic biomarker in ccRCC. a Venn-diagram analyses of candidate genes from the TCGA database. b VSX1 mRNA expression in diverse human malignancies. Statistical significance was calculated using the Wilcoxon test. c VSX1 mRNA expression was higher in ccRCC tissue than in the adjacent normal tissue in the TCGA database. The significance of the difference was evaluated using the paired Student’s t-test. d VSX1 mRNA expression was analyzed in different pathological stages for ccRCC in the TCGA database. The significance of the difference was evaluated using unpaired Student’s t-test. *P < 0.05, ** P < 0.01, and *** P < 0.001