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. 2022 Dec 3;20:554. doi: 10.1186/s12967-022-03772-2

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — High VSX1 expression promoted tumor invasion in ccRCC by transcriptional activation. a The mRNA expression of VSX1-correlated genes was validated in the GSE40435 dataset. b The gene-correlation analysis was validated on GSE40435 by Spearman’s correlation coefficient. c − e qRT-PCR assay of relative mRNA expression of TMEM44, FKBP10, and TRIB3 in 20 pairs of clinical ccRCC tissues. f − h Dual-luciferase reporter gene analysis of transcriptional activation for VSX1. i − j qRT-PCR analysis of relative mRNA expression of TMEM44, FKBP10, and TRIB3 in 786-O and Caki-1 cells. k − l CCK-8 and colony formation evaluated the proliferation capacity for FKBP10 knockdown after VSX1 overexpression in 786-O cells. Paired or unpaired Student’s t-tests and one-way analysis of variance were used to assess the significance of differences. Data were presented as the mean ± standard deviation. *P < 0.05, ** P < 0.01, and *** P < 0.001