Figure 1.

Changes in clinical parameters before and after benralizumab treatment (A) Change in FEV₁ from baseline in the bio-naïve group and switching group (B) Number of annual exacerbations in all patients, the bio-naïve group and the switching group (C) Change in ACT score from baseline in the bio-naïve group and switching group (D) Reduction rate of the OCS dose from baseline in the bio-naïve group and switching group. All data are presented as the mean. In (A), (B) and (C), the data were analyzed using the Wilcoxon signed-rank test. The upper and lower bars represent the standard errors in (A) and (C). *P < 0.05 compared with pre-BEN. **P < 0.05 compared with pre-MEP. ^†P <0.01 compared with pre-MEP.

Abbreviations: ACT, Asthma Control Test; FEV₁, forced expiratory volume in one second; BEN, benralizumab; MEP, mepolizumab; pre-BEN or pre-MEP, pretreatment with BEN or MEP; m, month(s); n, number of patients for whom clinical data were available; OCS, oral corticosteroid.