Table 2.
Change from Baseline After 2 Years in Asthma Patients with or Without Previous Biologics
| All Patients (n=23) | Biologics-Naïve (n=13) | Previous Mepolizumab (+) (n=10) | P value Between Two Groups At Baseline | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Baseline | After 2 Years | P value | Baseline | After 2 Years | P value | Baseline | After 2 Years | P value | P value | |
| Peripheral blood eosinophil counts (/µL) | 605 (1354) | 43 (200) | <0.0001 | 971 (1736) | 74 (266) | 0.002 | 130 (137) | 3 (7) | 0.008 | <0.001 |
| Peripheral blood basophil counts (/µL) | 53 (56) | 16 (19) | 0.0002 | 62 (65) | 13 (14) | 0.002 | 41 (42) | 19 (25) | 0.037 | 0.40 |
| Serum IgE (IU/mL) | 249 (233) | 174 (181) | 0.033 | 301 (242) | 202 (207) | 0.11 | 181 (213) | 140 (149) | 0.14 | 0.15 |
| FeNO (ppb) | 71 (52) | 68 (46) | 0.60 | 73 (52) | 73 (48) | 0.66 | 69 (56) | 62 (44) | 0.09 | 0.80 |
| %FVC (%) | 92.3 (14.7) | 101.5 (14.0) | 0.01 | 94.1 (18.1) | 106.0 (15.6) | 0.02 | 90.0 (9.1) | 95.2 (8.9) | 0.24 | 0.60 |
| %FEV1 (%) | 76.7 (22.9) | 84.3 (18.4) | 0.016 | 77.4 (28.4) | 86.8 (22.0) | 0.11 | 75.7 (14.2) | 80.9 (12.6) | 0.042 | 0.95 |
| FEV1/FVC (%) | 67.0 (11.5) | 67.8 (11.5) | 0.47 | 65.5 (12.3) | 66.4 (12.9) | 0.48 | 69.0 (10.6) | 69.7 (9.6) | 0.12 | 0.58 |
| FEV1 (mL) | 1923 (556) | 2101 (528) | 0.045 | 1828 (716) | 2007 (657) | 0.18 | 2048 (205) | 2230 (259) | 0.12 | <0.01 |
| %PEF (%) | 84.7 (25.7) | 85.7 (23.0) | 0.43 | 86.9 (30.4) | 91.7 (24.9) | 0.93 | 81.8 (19.0) | 77.4 (18.4) | 0.26 | 0.95 |
| ACT (pts) | 18.8 (5.2) | 21.7 (3.9) | 0.0007 | 18.0 (5.4) | 22.1 (3.5) | 0.009 | 19.8 (5.1) | 21.2 (4.4) | 0.027 | 0.51 |
| Number of annual exacerbations | 2.5 (3.3) | 0.74 (1.7) | 0.014 | 3.2 (4.0) | 0.92 (1.9) | 0.049 | 1.5 (2.1) | 0.5 (1.3) | 0.17 | 0.44 |
| Prednisolone equivalent dose (mg/day) (n=9) | 6.0 (3.6) | 2.9 (2.4) | 0.07* | 6.8 (4.1) | 2.2 (2.4) | 0.07 | 4.5 (1.8) | 4.5 (1.8) | ― | 0.50 |
Notes: Data are presented as the mean (standard deviation) and were analyzed using the Wilcoxon signed rank test. *Prednisolone equivalent dose significantly decreased to 2.6 (2.1) mg/day at last follow-up (P = 0.042).
Abbreviations: ACT, Asthma Control Test; FeNO, fractional exhaled nitric oxide; FEV1, forced expiratory volume in one second; FVC, forced volume capacity; PEF, peak expiratory flow.