Table 1. Characteristics of the patients.

AMD: monthly acute medication intake days; CM: chronic migraine; EM: episodic migraine; HIT-6: Headache Impact Test-6; IQR: interquartile range; TTH: tension-type headache; MHD: monthly headache days; MOH: medication-overuse headache

Case number	Age (years)	Diagnosis	Comorbidities	Medication	Onset age	0-month HIT-6	0-month MHD	0-month AMD	Prescribed prophylactic medication	1-month HIT-6	1-month MHD	1-month AMD	3-month HIT-6	3-month MHD	3-month AMD
1	28	EM	Dysmenorrhea	Low-dose pill	10	55	1	1	Propranorol, goreisan, goshuyuto	51	1	1	49	1	1
2	50	EM	Oral cancer	-	40	58	14	8	Propranorol, goreisan, goshuyuto	54	10	4	50	8	3
3	54	EM	-	-	22	64	4	4	Propranorol, goreisan	46	1	1	45	0	0
4	25	EM+MOH	Dysmenorrhea	Low-dose pill	17	63	10	12	Valproic acid, goreisan, goshuyuto	63	4	8	57	4	4
5	28	EM+TTH＋MOH	-	-	16	64	28	12	Did not want	64	28	8	Referred to another clinic
6	26	EM+TTH+MOH	-	-	21	64	28	28	Amitriptyline, goreisan, goshuyuto	54	14	8	Referred to another clinic
7	32	CM+MOH	-	-	26	62	16	16	Valproic acid, goreisan, goshuyuto	61	18	2	54	6	3
8	61	TTH	-	-	18	55	28	0	Goreisan, yokukansan	53	17	0	54	14	0
Median (IQR)	30 (28-51)	-	-	-	20 (17-23)	63 (57-64)	15 (9-28)	10 (3-13)	-	54 (53-62)	12 (3-17)	3 (1-8)	52 (49-54)	5 (2-8)	2 (0-3)