Zhou 2002.

Methods	Design: randomised controlled trial. Multi‐centre or single‐centre: single‐centre.Period: not reported. Sample size calculation: not reported. Generation of allocation: random numbers table. Allocation concealment: not reported.Blinded assessment of treatment allocation: not reportedWithdrawals: no withdrawals. Intention‐to‐treat analysis: not reported.Follow‐up: not reported
Participants	30 recruited: 15 in each group Mean age: treatment group 42 ± 3.4 years; control group 36.8 ± 4.6 years Mean total burn surface area (TBSA): treatment group 66.1 ± 5.2% with 38.1 ± 6.2% TBSA, 3rd‐degree burns; control group 62.6 ± 8.1% with 36.6 ± 4.8% TBSA, 3rd‐degree burns Inclusion criteria: admission to the burn unit within 6 hours post injury, TBSA 30% to 60%, 3rd‐degree burn > 20% TBSA, age 18 to 60 years Exclusion criteria: inhalation injury
Interventions	Experimental (n = 15): glutamine dipeptide powder 0.5 g/kg/d (oral with warm water). Treatment lasted 12 days. 2nd‐degree and 3rd‐degree burn wounds received SD‐Ag. Most 3rd‐degree burn wounds received escharotomy and skin grafting on day 5 post injury. Participants in shock received fluid resuscitation Control (n = 15): Same amount of placebo was given according to the same instructions as for the treatment group. All other interventions were the same
Outcomes	Length of stay Wound healing
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Random numbers table
Allocation concealment (selection bias)	Unclear risk	Not reported
Blinding (performance bias and detection bias) All outcomes	Unclear risk	Not reported
Incomplete outcome data (attrition bias) All outcomes	Low risk	All participants analysed
Other bias	High risk	ITT not reported, sample size calculation not reported