Table 4.

Incidence and severity of treatment-emergent AEs by median age.

n (%)	Median Split Age <44 y		Median Split Age ≥44 y
	KarXT (n = 43)	Placebo (n = 46)	KarXT (n = 46)	Placebo (n = 44)
Any AE	23 (53.5)	24 (52.2)	25 (54.3)	15 (34.1)
Any mild AE	22 (51.2)	19 (41.3)	19 (41.3)	13 (29.5)
Any moderate AE	6 (14.0)	10 (21.7)	9 (19.6)	3 (6.8)
Any severe AEa	1 (2.3)	1 (2.2)	0	0

^aA severe AE was defined as any event that was incapacitating or caused an inability to perform normal activities of daily living.

AE adverse event.