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. 2022 Dec 3;8:478. doi: 10.1038/s41420-022-01259-z

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A 4311 cells of 176P and 2936 cells of 176R were divided into nine clusters by k-means algorithm, respectively. B Heatmaps showed the top 50 upregulated genes in each cluster compared to other eight clusters of 176P and 176R tissues. C Shared genes between clusters in the same samples or between clusters in different samples. D Some differentially expressed shared genes in different clusters of 176P and 176R tissues. Cluster 6 and cluster ix, v, iv were highlighted. Dashed lines represented log2 average expression of cells in both samples.