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. 2022 Dec 3;8:478. doi: 10.1038/s41420-022-01259-z

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — Mice (n = 4 per group) were treated with vehicle, Trastuzumab alone, inhibitors alone, and inhibitor combined with Trastuzumab for 21 days. (A CAN017; B trametinib; C BEZ235; D JQ1; E SHR6390). Tumor volume was calculated and tumor growth curve was plotted, as well as the TGI and relative weight of the initial treatment. The related protein expressions were also displayed in each figure. TGI tumor growth inhibition, tras Trastuzumab, CAN CAN017, tram trametinib, BEZ BEZ235, SHR SHR6390.