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. 2022 Dec 3;5:1326. doi: 10.1038/s42003-022-04298-5

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a–c Dot plot showing the scaled expression of several key biological function-related gene sets of each cluster in mucosa. Gene sets were downloaded from the Molecular Signatures Database (MSigDB). The color gradient represents the average expression of each gene in each cluster scaled across all clusters. The dot size represents the percentage of positive cells in each cluster. The colors representing each cluster in the color band correspond to those in Fig. 1a. a Genes encoding structural components of basement membranes (M5887) and collagen proteins (M3005). b Genes encoding core extracellular matrix components, including ECM glycoproteins, collagens and proteoglycans (M5884), excluding the genes contained in Fig. 4A. c Genes encoding cytokines (GO:0005125) and growth factors (GO:0008083). d Gene Ontology analysis of marker genes for each cluster. e KEGG enrichment analysis of marker genes for each cluster.