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. 2022 Dec 3;12:20879. doi: 10.1038/s41598-022-24584-w

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Significant gene overlaps in network curvature and differential expression. Venn diagram of the number of statistically significant genes identified by PPI network Forman-Ricci curvature in the 1D graph model (FR_1D) and 2D complex model (FR_2D) along with classic differential gene expression (DE).