TABLE 3.
Associations between APOE allele and cognitive function
| Caribbean Hispanicsc N = 5947 |
Hispanic Americansd N = 576 |
Blacks/African Americansd N = 917 |
Non-Hispanic White Americansd N = 6070 |
|
|---|---|---|---|---|
| Panel A: Dementia status a | ||||
| Any ε4 | 1.92 [1.62–2.22] | 1.64 [0.81–2.47] | 1.26 [0.81–1.71] | 1.83 [1.26–2.40] |
| Any ε2 | 0.87 [0.65–1.09] | 0.82 [0.07–1.56] | 1.26 [0.78–1.74] | 1.01 [0.60–1.42] |
| Panel B: Immediate recall b | ||||
| Any ε4 | 0.94 [0.92–0.96] | 0.95 [0.88–1.03] | 0.96 [0.92–1.01] | 0.95 [0.93–0.96] |
| Any ε2 | 1.00 [0.98–1.03] | 1.04 [0.94–1.16] | 0.98 [0.93–1.03] | 1.00 [0.98–1.02] |
| Panel C: Delayed recall b | ||||
| Any ε4 | 0.90 [0.87–0.93] | 0.91 [0.81–1.03] | 0.84 [0.76–0.93] | 0.91 [0.88–0.93] |
| Any ε2 | 1.00 [0.96–1.04] | 1.10 [0.96–1.25] | 0.98 [0.88–1.09] | 1.01 [0.98–1.05] |
Coefficients reported in Panel A are prevalence ratios (PRs) estimated from logistic regressions with dementia status as the dependent variable. PRs are interpreted as the ratios of estimated dementia prevalence between those with a particular APOE allele (e.g., ε4) to those without the allele in each sample. Ninety-five percent confidence intervals of the PRs are in brackets. All regressions adjusted for age, age squared, sex, and education.
Coefficients reported in Panels B and C are incidence rate ratios (IRRs) estimated from Poisson regressions with number of correct words recalled in 10-word immediate recall (Panel B) and 10-word delayed recall (Panel C) as the dependent variable. IRRs are interpreted as the ratios of expected number of words recalled between those with a particular APOE allele to those without the allele in each sample. Ninety-five percent confidence intervals of the IRRs are in brackets. All regressions adjusted for age, age squared, sex, and education.
Country indicators were additionally adjusted for the Caribbean Hispanics sample.
Prevalence ratios, incidence rate ratios, and their confidence intervals for US samples are from weighted regressions using person-level analytic weights. Number of observations for each sample is unweighted.
Abbreviation: APOE, apolipoprotein E.