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. 2022 Dec 3;19:289. doi: 10.1186/s12974-022-02651-3

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig.2 — Time course and cellular localization of TREM2. A Representative Western blot bands of TREM2 expression at the lesion site over time. B Quantitative analysis of TREM2 time course expression. *p < 0.05 vs. Sham group. n = 6 per group. C Representative images of the colocalization of TREM2 (green) with microglia (Iba1, red), neurons (NeuN, red), and astrocytes (GFAP, red) at the lesion site at 3 d after CCI. Nuclei were stained with DAPI (blue). Scale bar = 100 μm, n = 3. D Brain sample with schematic illustration showing the area (indicated by black box) used for immunofluorescence analysis. E Quantitative analysis of the percentage of TREM2-Iba1⁺ cells to Iba1⁺ cells, TREM2-NeuN⁺ cells to NeuN⁺ cells, and TREM2-GFAP⁺ cells to GFAP⁺ cells. n = 3