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. 2022 Dec 3;19:289. doi: 10.1186/s12974-022-02651-3

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — The Akt/CREB/BDNF axis participated in the neuroprotective effects of TREM2 activation. A Representative images of BDNF (green) surrounding the lesion sites at 3 d after CCI. Scale bar = 50 μm. B Quantitative analysis of the relative BDNF fluorescence intensity surrounding the lesion sites after CCI. *p < 0.05 vs. Sham; ^#p < 0.05 vs. CCI + Vehicle, n = 6 per group. C Representative Western blot bands of TREM2, p-Akt, Akt, p-CREB, CREB, BDNF, and β-Actin at the lesion sites after CCI. D–G Quantitative analysis of TREM2 (D), p-Akt (E), p-CREB (F), and BDNF (G) density at the lesion sites after CCI. *p < 0.05 vs. Sham; ^#p < 0.05 vs. CCI + Vehicle, n = 6 per group