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. 2022 Dec 3;20:509. doi: 10.1186/s12951-022-01703-3

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — Schematic illustration of charge-reversal semiconducting polymer nano-modulator (SP_DMCN)-mediated photodynamic cancer immunotherapy. a Chemical structure and self-assembly of SP_DMCN, and the mechanism of pH-responsive charge-reversal and immunomodulator (NCTD) release. b Illustration of SP_DMCN-mediated synergistic immunotherapy, including acidic tumor microenvironment induced (NCTD) release, photoirradiation of SP_DMCN for ICD induction, and immune cell modulation by NCTD. Reproduced with permission from reference [160]. Copyright 2021, JOHN/WILEY & SONS, INC