Table 3.
Concentration of cytokines/chemokines after LPS stimulation
| HC | AFF | NON | |||||
|---|---|---|---|---|---|---|---|
| Median | (IQR) | Median | (IQR) | Median | (IQR) | ||
| Growth factors | G-CSF | 7004 | (3616–10,607) | 5839 | (3855–11,409) | 7026 | (3560–10,522) |
| GM-CSF | 951.5 | (411.9–1662) | 2076# | (863.6–2998) | 1157 | (758.4–2120) | |
| IL-7 | 147.1 | (97.3–220.9) | 130.4 | (91.93–253.3) | 149.5 | (81.36–219) | |
| Innate inflammatory cytokines | TNF-α | 667.3 | (307.1–1665) | 1081* | (475–2501) | 549.8 | (265.9–1206) |
| TNF-β | 10.07 | (7.21–18.99) | 18.430 | (10.46–30.52) | 13.73 | (7.79–20.32) | |
| IL-1α | 676.5 | (417.6–931.3) | 979.1 | (375.7–1274) | 621.2 | (423.4–1001) | |
| IL-1β | 872.3 | (478.3–1708) | 1884 | (499.7–2849) | 932.4 | (499.4–1326) | |
| IL-6 | 24,378 | (17,727–34,327) | 25,326 | (18,675–28,548) | 22,498 | (9904–28,025) | |
| IL-15 | 2.045 | (0.6–6.293) | 2.365 | (0.6–5.453) | 5.39*† | (2.958–13.53) | |
| IFNα2 | 65.52 | (44.42–89.09) | 93.99 | (42.76–168.3) | 91.28† | (65–139.3) | |
| Innate inflammatory chemokines | Eotaxin | 232.7 | (172–388.3) | 325.6* | (227.8–657.8) | 226.6 | (179.4–312.5) |
| IL-8 | 28,706 | (22,063–42,134) | 32,535 | (29,256–42,602) | 29,426 | (22,479–38,281) | |
| IP-10 | 123.6 | (94.64–163.4) | 173.7 | (103.4–299.4) | 117.2 | (92.26–178.3) | |
| MCP-1 | 21,723 | (12,959–28,732) | 20,693 | (16,627–23,984) | 18,618 | (8496–22,436) | |
| MIP-1β | 2863 | (351.6–5706) | 3781 | (1342–7966) | 2291 | (1241–5973) | |
| TH1 cytokines | IFNγ | 163.1 | (116.5–273.6) | 251.3 | (178.3–424.4) | 166.7 | (133.8–283.5) |
| IL-2 | 9.75 | (4.65–14.7) | 11.7 | (5.085–26.12) | 10.82 | (6.228–26.73) | |
| IL-12p40 | 229.3 | (151.9–287.5) | 292.5 | (92.7–501) | 249.6 | (176.4–328.5) | |
| IL-12p70 | 106.9 | (48.68–126) | 110.5 | (48.35–208) | 97.32 | (61.34–130.6) | |
| TH2 cytokines | IL-4 | 14.66 | (7.29–27.71) | 19.59 | (7.705–57.5) | 20.34 | (12.96–45.41) |
| IL-5 | 3.3 | (0.25–5.36) | 2.97 | (0.25–4.52) | 3.42 | (0.465–5.375) | |
| IL-13 | 29 | (14.2–46.44) | 33.33 | (16.71–86.75) | 26.02 | (19.9–42.24) | |
| TH17 cytokine | IL-17 | 17.04 | (8.29–20.41) | 20.91# | (10.73–53.02) | 14.53 | (9.393–21.33) |
| Regulatory cytokines | IL-10 | 1321 | (654–2257) | 1071 | (302.4–1709) | 1228 | (594.4–1654) |
| TGF-β | 2063 | (1213–3724) | 1893 | (911.4–3610) | 2728 | (1763–3831) | |
# p value < 0.05 when comparing AFF with HC
* p value < 0.05 when comparing AFF with NON
† p value < 0.05 when comparing NON with HC