Table 4.
Concentration of cytokines/chemokines after PHA stimulation
| HC | AFF | NON | |||||
|---|---|---|---|---|---|---|---|
| Median | (IQR) | Median | (IQR) | Median | (IQR) | ||
| Growth factors | G-CSF | 1073 | (176.2–5540) | 1742 | (507.6–3131) | 1568 | (502.1–3992) |
| GM-CSF | 2052 | (1068–4299) | 2688 | (1174–7231) | 2144 | (1210–4119) | |
| IL-7 | 230.8 | (155.2–356.2) | 212.6 | (174.7–364.8) | 207.8 | (153.6–376.2) | |
| Innate inflammatory cytokines | TNF-α | 1788 | (660–3352) | 2935 | (1398–5679) | 1439 | (744.5–3003) |
| TNF-β | 132.4 | (45.81–249.9) | 90.850 | (60.01–225.2) | 94.32 | (52.81–259.4) | |
| IL-1α | 255.1 | (119.7–483.3) | 260.3 | (142.4–490.1) | 147 | (71.45–383.6) | |
| IL-1β | 397 | (163.2–701.5) | 435.8 | (294.9–924.8) | 423.1 | (185.2–666.8) | |
| IL-6 | 12,379 | (4432–32,676) | 14,652 | (10,115–38,533) | 14,463 | (8887–29,259) | |
| IL-15 | BLD | ( -) | BLD | ( -) | BLD | ( -) | |
| IFNα2 | 143.5 | (107.3–255.6) | 169.3 | (105.9–271.6) | 233.9 | (94.19–308.3) | |
| Innate inflammatory chemokines | Eotaxin | 437.1 | (332.3–538.4) | 579.6# | (427.6–1159) | 491.5 | (390.6–721.6) |
| IL-8 | 58,839 | (45,963–72,654) | 72,251 | (60,626–79,861) | 62,381 | (46,572–73,048) | |
| IP-10 | 1636 | (737.4–2676) | 674.7 | (507.4–1881) | 1110 | (346.7–2251) | |
| MCP-1 | 45,328 | (32,987–56,223) | 46,623 | (40,973–53,608) | 42,272 | (36,682–55,723) | |
| MIP-1β | 8413 | (3240–14,641) | 9661 | (4050–17,779) | 6455 | (2483–11,844) | |
| TH1 cytokines | IFNγ | 1173 | (561.6–8849) | 4341* | (1063–11,102) | 851.6 | (450.8–1678) |
| IL-2 | 38.67 | (19.71–88.13) | 43.55 | (21.72–94.29) | 34.23 | (22.01–85.62) | |
| IL-12p40 | 469.1 | (279.1–550.6) | 463.9 | (314.4–679.1) | 416.5 | (317.4–586.8) | |
| IL-12p70 | 233.7 | (122.4–339.8) | 257.7 | (126.7–344.4) | 212.6 | (117.7–255.6) | |
| TH2 cytokines | IL-4 | 54.87 | (25.72–83.06) | 95.57 | (37.74–124.6) | 64.69 | (34.19–111.5) |
| IL-5 | 31.31 | (5.283–55.71) | 37.21 | (12.36–66.15) | 29.31 | (5.013–70.01) | |
| IL-13 | 547 | (189.5–1356) | 920.7 | (273.3–2179) | 845.5 | (232.2–1494) | |
| TH17 cytokine | IL-17 | 171.8 | (109.4–261.1) | 225.2 | (114.4–336.9) | 198.8 | (113–415.3) |
| Regulatory cytokines | IL-10 | 634.2 | (267.4–1287) | 534.4 | (306.3–918.8) | 547.6 | (233–1017) |
| TGF-β | 2460 | (1253–3338) | 2056 | (1233–4097) | 2530 | (1506–3467) | |
BLD below the limit of detection
# p value < 0.05 when comparing AFF with HC
* p value < 0.05 when comparing AFF with NON
† p value < 0.05 when comparing NON with HC