Table 6.

In vivo Synergistic Effect of Licorice with Various Anticancer Drugs

Metabolites of Licorice	Anticancer Drugs	Type of Cancer	Model	Antitumor Effects	Mechanisms	Reference
Liquiritigenin	Cisplatin	Melanoma	Female C57 BL/6 black mice	Suppressed cell migration and cell invasion	↓PI3K/Akt	[257]
Licoricidin	Gemcitabine	Osteosarcoma	Female BALB/c nude mice	Enhanced cytotoxicity	↓Akt and NF-κB	[261]
Licochalcone A	Cisplatin	Colon carcinoma	BALB/c mice	Suppressed cell proliferation	↓DNA synthesis	[262]
Isoliquiritigenin	Cyclophosphamide	Cervical Cancer	KM mice	Suppressed cell proliferation	DNA strand break	[260]

Abbreviations: NF κB, nuclear factor kappa-light-chain-enhancer of activated B cells; PI3K, phosphoinositide 3-kinase.