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Peptide 7 has limited pharmacologic action at the GLP-1R, but retains antagonism at the hGcgR. Antagonistic (A, B, E, F) and agonistic (C, D, G, H) effect of 7 on cAMP signaling GLP-1 at the hGLP-1R (A, C) mGLP-1R (B, D) and glucagon (Gcg) at the hGcgR (E, G) and mGcgR (F, H). Data represent the mean ± SEM of a duplicate experiment.
