Figure 2.

SPMs stimulate mitochondrial metabolism in peritoneal macrophages. (A) PM from non-exercised mice were treated without or with 1 nM of the indicated SPM (RvD1, RvD2, RvE1, or MaR1) for 1h prior and throughout OCR and ECAR measurements of a mitochondrial stress assay. (B) Derived mitochondrial respiratory parameters were quantified and (C) fold changes of each respiratory parameter for each SPM treatment vs control are summarized in radar plots. Data expressed as mean ± SEM, n = 3 for all groups; ∗∗P < 0.01, ∗∗∗P < 0.001; One-way ANOVA with Holm-Šídák post-test.