Figure 1.

Gazelle-Multispectral for screening hemoglobin variants in newborns. (A) Gazelle-Multispectral platform for paper-based microchip electrophoresis using disposable cartridge (red box) at the point of need. (B) Hemoglobin absorption spectrum. Purple shaded area covers more than 90% of the power output according to the LED manufacturing specification and our internal testing. The Gazelle-Multispectral perform real time imaging and data analysis tracking the Hb electrophoresis process under both white light illumination (C) and 410 nm illumination (D). The images captured under white light illumination provides visual validation of test progression. (E) The space-time plots generated based on the images captures under 410 nm illumination are used for identifying and quantifying Hb variants in real time using an internally integrated data analysis algorithm. (F) At the end of each test, Gazelle-Multispectral algorithm automatically reports the identification and quantification of Hb variant results, and determines the patient phenotype accordingly.